Anti-Bim antibody

Bim is a protein encoded by the BCL2L11 gene which is approximately 22,1 kDa. Bim is localised to the mitochondrion. It is involved in the activation of BH3-only proteins, apoptosis modulation and signalling, p75 NTR receptor-mediated signalling and MAPK signalling. It forms a hetero- or homodimers and acts as anti- or pro-apoptotic regulator that is involved in a wide variety of cellular activities. Bim isoform gamma is most abundantly expressed in small intestine and colon. Other isoforms are widely expressed with tissue-specific variation. Mutations in the BCL2L11 gene may result in ocular hyperemia and autoimmune lymphoproliferative syndrome. STJ91855 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bim.