Anti-Bad antibody

Bad is a protein encoded by the BAD gene which is approximately 18,4 kDa. Bad is localised to the mitochondrion outer membrane and cytoplasm. It is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, glioma and the development HGF signalling pathway. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. It also appears to act as a link between growth factor receptor signalling and the apoptotic pathways. Bad is widely expressed in a wide variety of tissues. Mutations in the BAD gene may result in adrenal cortical adenocarcinoma and endometrial cancer. STJ91800 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bad protein.